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Pancreatic enzyme elevation in measles

N Cohen¹, A Golik, A Blatt

¹Department of Internal Medicine, A, Assaf Harofeh Medical Center, Zerifin, Israel.

Journal of Clinical Gastroenterology

|December 1, 1994

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Severe measles can cause pancreatic damage in young adults, indicated by elevated amylase and lipase levels. This study highlights potential organ complications during measles outbreaks.

Area of Science:

Virology
Gastroenterology
Internal Medicine

Background:

Measles is a highly contagious viral illness.
While typically associated with respiratory symptoms, systemic complications can occur.
Previous literature has not extensively detailed pancreatic involvement in adult measles cases.

Observation:

A prospective study investigated nine young adults hospitalized with severe measles.
Patients presented with symptoms including abdominal pain and vomiting.
Biochemical markers were used to assess organ involvement.

Findings:

Elevated serum and urinary amylase levels were observed in most patients.
Serum lipase was elevated in seven out of eight patients.
Hepatobiliary enzymes (AST, ALT, LDH) and hypocalcemia were common; thrombocytopenia was noted in four patients.

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Implications:

This study provides the first detailed report of pancreatic involvement in young adults with severe measles.
Elevated pancreatic enzymes suggest a potential mechanism for gastrointestinal symptoms during measles.
Further research is warranted to understand the underlying mechanisms and clinical significance of measles-associated pancreatitis.