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Development of intra-arterial hyperthermia using a dextran-magnetite complex

M Mitsumori¹, M Hiraoka, T Shibata

¹Department of Radiology, Faculty of Medicine, Kyoto University, Japan.

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

|November 1, 1994

Summary

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Dextran-magnetite complex (DM) magnetic fluids enable targeted tissue heating. Developed embolic materials with DM successfully embolized rabbit renal arteries and achieved localized hyperthermia, suggesting potential for cancer treatment.

Area of Science:

Biomaterials science
Nanotechnology
Medical physics

Background:

Dextran-magnetite complex (DM) is a magnetic fluid with high specific absorption rate.
Existing ferrite particles have lower heat generation efficiency compared to DM.

Purpose of the Study:

To develop DM-containing embolic materials for targeted tissue hyperthermia.
To evaluate the efficacy of these materials in embolization and localized heating.

Main Methods:

Formulation of two DM-based embolic materials: DM/Lipiodol emulsion and DM/degradable starch microsphere suspension.
In vitro assessment of heat-generating capacity.
In vivo embolization and hyperthermia in rabbit renal arteries using an AC magnetic field.
Histological examination of embolized tissue.

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Main Results:

DM's heat-generating capacity remained intact in the embolic material formulations.
Successful embolization of renal arteries and selective hyperthermia of the kidney were achieved in rabbits.
Homogeneous distribution of DM within the embolized kidney was confirmed histologically.

Conclusions:

DM-containing embolic materials are effective for both embolization and inductive hyperthermia.
These materials show promise for targeted cancer treatment applications.
Further research into DM-based therapies is warranted.