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Neurotransmitters and cytokines in CNS pathology
B Mitrovic1, F C Martin, A C Charles
1UCLA School of Medicine 90024.
Progress in Brain Research
|January 1, 1994
Abstract:
In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied.