The place of symmetry in the study of biological macromolecules

The various aspects of symmetry involved in discussions of biological macromolecules are analysed. Among these are geometrical symmetry of the macromolecule itself, the symmetry of its binding isotherms and the underlying thermodynamic and mathematical relations, the role of symmetry in different allosteric models, and the effect of symmetry on the number of relaxation times shown by a macromolecule in its approach to equilibrium or a steady state. Finally there is the symmetry of the group of potentials and the resulting linkage relations which govern the response of the macromolecule to its ligands and embody the grammar of a macromolecular language.