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Translocation t(3;12)(q28;q14) in parosteal lipoma
J A Bridge1, J DeBoer, C W Walker
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5440.
Genes, Chromosomes & Cancer
|January 1, 1995
Summary
Parosteal lipomas, rare bone tumors, share genetic similarities with common soft tissue lipomas. This finding suggests a common origin for both types of lipomas.
Area of Science:
- Oncology
- Genetics
- Orthopedics
Background:
- Parosteal lipoma is a rare benign bone tumor.
- Soft tissue lipomas commonly exhibit 12q13-15 abnormalities.
Observation:
- Cytogenetic analysis was performed on a parosteal lipoma of the femur.
Findings:
- The parosteal lipoma revealed a translocation t(3;12)(q28;q14).
- This genetic finding is similar to those observed in soft tissue lipomas.
Implications:
- Bone and soft tissue lipomas are cytogenetically similar.
- This suggests a shared histopathogenesis for both tumor types.