[Molecular mechanisms underlying the relationship of motivation and supporting stimulation in brain neurons]

The nature of neuronal impulse activities in the sensory area of the brain was studied in rats given ouabain and cycloheximide by electric stimulation of the cold center of the lateral hypothalamus in the presence or absence of readily available feed. Microionophoretic administration of ouabain into the cortical neurons resulted in similar charges in the impulse effects of nerve cells on the stimulation of the lateral hypothalamus both in the presence and in the absence of the feed available to the animals. That of cycloheximide led to significant changes in the frequency of discharge activities of the cells that had initially shown their response to electric irritation of the lateral hypothalamus in the presence of the feed readily available to the animals.