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Cellular and extracellular components at nodes of Ranvier in rat white matter
C Bjartmar1, B Karlsson, C Hildebrand
1Department of Cell Biology, Faculty of Health Sciences, University of Linköping, Sweden.
Brain Research
|December 19, 1994
Abstract:
Rat CNS nodes of Ranvier were investigated by electron microscopy and immunohistochemistry. Nodes along thin callosal axons possess tiny node gaps containing few or no astrocytic processes. Nodes along thick spinal axons exhibit spatious node gaps containing relatively few irregularly arranged astrocytic processes. Antibodies against HNK-1, chondroitin sulfate, tenascin or NSP-4 do not label small nodes but stain large nodes. We conclude that rat CNS fibers do not exhibit a strict relation between nodal complexity and fiber size comparable to that found in rat PNS fibers.