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Multiple myeloma

J Cuzick1

  • 1Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London.

Cancer Surveys
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Mortality trends for multiple myeloma (a blood cancer) show increasing rates in Japan and the British Isles, while stabilizing in high-rate countries like Sweden. Older age groups experienced greater mortality increases.

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Area of Science:

  • Epidemiology
  • Cancer Research
  • Public Health

Background:

  • Multiple myeloma mortality trends have varied globally.
  • Understanding these trends is crucial for public health interventions.
  • Previous studies indicated differing patterns across nations.

Purpose of the Study:

  • To analyze multiple myeloma mortality trends from 1960 to 1989 across 20 countries.
  • To investigate detailed patterns in England and Wales, Sweden, and Japan.
  • To examine age-specific and sex-specific mortality rate changes.

Main Methods:

  • Retrospective analysis of mortality data from 1960 to 1989.
  • Comparison of trends across 20 countries, with in-depth analysis for select nations.
  • Examination of age-standardized mortality rates and male:female ratios.

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Main Results:

  • Mortality increases were more pronounced in older age groups.
  • Rate increases slowed in the most recent decade (1980s) compared to prior decades.
  • Stable rates observed in high-rate countries (e.g., Sweden), while low-rate countries (e.g., Japan) showed continued increases.
  • The male:female mortality ratio approached 1.45, higher in high-rate countries and potentially increasing.
  • The British Isles exhibited relatively high and steadily increasing mortality rates.

Conclusions:

  • Multiple myeloma mortality trends show distinct geographical and temporal variations.
  • The British Isles represent a region of concern due to persistently high and increasing rates.
  • Further research is needed to understand the drivers of these divergent trends.