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Monoclonal IgM reactive with several gangliosides in a chronic relapsing polyneuropathy
I Brindel1, J L Preud'homme, J M Vallat
1Laboratories of Immunology, Limoges University Hospital, France.
Neuroscience Letters
|November 7, 1994
Abstract:
A possibly pathogenic serum monoclonal IgM lambda from a patient with chronic relapsing polyneuropathy was shown to react with the disialosyl-lactosyl residue (NeuAc alpha 2-8NeuAc alpha 2-3) -Gal beta 1-4Glc expressed by GD1b, GT1b, GQ1b, GD2 and GD3. A part of this epitope in terminal position in GM3, GD1a and LM1 was also recognized by the IgM lambda.