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Related Experiment Videos

A new urinary test for stone "activity"

P C Hallson, G A Rose

    British Journal of Urology
    |December 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Rapid urine evaporation causes crystal formation, particularly in stone formers. Combined thiazide and cellulose phosphate therapy effectively reduced crystalluria, suggesting inhibitors are crucial for preventing kidney stones.

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    Area of Science:

    • Nephrology
    • Urology
    • Crystallography

    Background:

    • Urine supersaturation is a key factor in calcium oxalate kidney stone formation.
    • Crystalluria, the presence of crystals in urine, is a marker for stone formation risk.
    • Evaporation tests can simulate conditions leading to crystal precipitation.

    Purpose of the Study:

    • To investigate the incidence of specific urinary crystals (Wedellite and calcium phosphate) after rapid urine evaporation.
    • To compare crystalluria incidence between normal subjects and kidney stone formers.
    • To evaluate the effects of thiazides and cellulose phosphate on preventing crystalluria.

    Main Methods:

    • Urine samples were rapidly evaporated to an osmolarity of 1200.
    • Crystalluria was assessed, and crystal types (Wedellite, calcium phosphate) were identified.

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  • Calcium and oxalate concentration products were calculated.
  • The impact of thiazide and cellulose phosphate therapies on crystalluria was examined.

    • Main Results:

    • Rapid urine evaporation induced high incidences of Wedellite and calcium phosphate crystals.
    • Stone formers exhibited higher crystalluria rates than normal subjects.
    • Thiazides reduced crystalluria, while cellulose phosphate increased it; combined therapy was most effective.
    • Calcium and oxalate concentration products did not correlate well with calcium oxalate crystalluria.

    Conclusions:

    • Evaporation tests can reveal crystalluria patterns similar to those in stone formers.
    • Inhibitors of crystal formation appear as important as concentration products in preventing kidney stones.
    • Evaporation tests may help identify individuals at risk for stone formation under dehydration or assess stone former metabolic activity.