Pre-operative arterial embolisation in renal carcinoma

Area of Science:

• Urology
• Interventional Radiology
• Oncology

Background:

• Nephrectomy for renal carcinoma frequently involves significant bleeding.
• Pre-operative renal artery occlusion can mitigate hemorrhage.
• Standard autologous clot embolization is limited by rapid clot lysis.

Purpose of the Study:

• To evaluate the efficacy of epsilon amino caproic acid (EACA)-stabilized autologous clot for renal artery embolization.
• To assess the impact of this technique on bleeding during nephrectomy.
• To determine the success of devascularization in patients undergoing nephrectomy for renal carcinoma.

Main Methods:

• In vitro experiments to assess clot stabilization with EACA.
• In vivo application of EACA-stabilized autologous clot for renal artery embolization in patients.
• Surgical nephrectomy following embolization.

Main Results:

• In vitro studies demonstrated successful stabilization of autologous clot with EACA.
• Satisfactory devascularization of the kidney and tumor was achieved in all 10 treated patients.
• The technique facilitated reduced bleeding during nephrectomy.

Conclusions:

• Epsilon amino caproic acid stabilization enhances the effectiveness of autologous clot embolization.
• This method provides a viable strategy for reducing intraoperative bleeding in nephrectomy for renal carcinoma.
• Successful devascularization supports the potential of this technique in oncological surgery.