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Endothelial cell adhesion molecules in psoriasis

M L Lee1, T To, E Nicholson

  • 1Department of Dermatology, Royal North Shore Hospital, St Leonards, NSW.

The Australasian Journal of Dermatology
|January 1, 1994
PubMed
Summary
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Psoriatic skin shows increased expression of endothelial cell activation markers, including intercellular adhesion molecule-1 (ICAM-1) and endothelial leukocyte adhesion molecule-1 (ELAM-1). These molecules may promote inflammatory cell infiltration in psoriasis.

Area of Science:

  • Dermatology
  • Immunology
  • Cell Biology

Background:

  • Psoriasis is a chronic inflammatory skin disease.
  • The role of cell adhesion molecules in psoriatic skin inflammation is not fully understood.

Purpose of the Study:

  • To investigate the expression of cell adhesion molecules in psoriatic skin.
  • To determine if these molecules contribute to inflammatory cell infiltration.

Main Methods:

  • Skin biopsies from psoriasis patients and healthy controls were analyzed.
  • Immunoperoxidase technique was used to detect intercellular adhesion molecule-1 (ICAM-1), endothelial leukocyte adhesion molecule-1 (ELAM-1), HECA-452, and 4D10.

Main Results:

  • Psoriatic skin exhibited increased expression of ICAM-1, ELAM-1, and 4D10 on endothelial cells.

Related Experiment Videos

  • ICAM-1 and HECA-452 were also found on leukocytes in psoriatic skin.
  • These adhesion molecules may facilitate inflammatory cell adhesion and infiltration.

    • Conclusions:

    • Psoriatic skin displays markers of endothelial cell activation.
    • Upregulated cell adhesion molecules likely play a role in leukocyte infiltration in psoriasis.