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Nitric oxide in inflammation and immunity

J E Albina1, J S Reichner

  • 1Department of Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence 02903, USA.

New Horizons (Baltimore, Md.)
|February 1, 1995
PubMed
Summary
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Nitric oxide (NO), produced from L-arginine by nitric oxide synthases, significantly impacts cellular physiology. Research on NO

Area of Science:

  • Biochemistry
  • Cellular Physiology
  • Molecular Biology

Background:

  • Nitric oxide (NO) is a critical signaling molecule.
  • Its production from L-arginine involves nitric oxide synthases (NOS).
  • Understanding NO's role is key to cellular physiology.

Purpose of the Study:

  • To review the comprehensive impact of NO production on cellular physiology.
  • To highlight the role of nitric oxide synthases in NO generation.
  • To provide a snapshot of current knowledge on NO's physiology and pathophysiology.

Main Methods:

  • Literature review of NO production and its effects.
  • Analysis of data on nitric oxide synthases.
  • Synthesis of current understanding of NO's physiological and pathophysiological roles.

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Main Results:

  • The discovery of NO production from L-arginine via NOS has profoundly impacted cellular physiology.
  • A vast amount of data is emerging on NO's roles.
  • Current knowledge represents a rapidly evolving field.

Conclusions:

  • Nitric oxide (NO) production is a fundamental process in cellular physiology.
  • Nitric oxide synthases are key enzymes in NO metabolism.
  • The field of NO research is dynamic and rapidly expanding.