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Related Experiment Videos

Sequential transplants using mobilized peripheral blood progenitor cells

R Ghalie1, C M Richman, J G Bender

  • 1Rush Medical Center, Chicago, IL 60612.

Journal of Clinical Apheresis
|January 1, 1994
PubMed
Summary
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High-dose therapy with mobilized peripheral blood progenitor cells (PBPC) supports rapid hematologic recovery in solid tumor patients. This approach enables intensified treatment, potentially improving patient outcomes in tandem transplant protocols.

Area of Science:

  • Hematology
  • Oncology
  • Stem Cell Transplantation

Background:

  • High-dose chemotherapy and bone marrow transplantation show limited success in solid tumors.
  • Intensified therapy may improve patient outcomes.
  • Mobilized peripheral blood progenitor cells (PBPC) offer rapid hematologic recovery, reducing transplant toxicity.

Purpose of the Study:

  • To evaluate a tandem transplant protocol using PBPC for solid tumors.
  • To assess the efficacy of PBPC mobilization and collection.
  • To compare hematologic recovery and engraftment rates.

Main Methods:

  • 42 patients with solid tumors received PBPC mobilized with cyclophosphamide, etoposide, and G-CSF.
  • Tandem transplants were performed using different myeloablative regimens.

Related Experiment Videos

  • PBPC collection involved 1-2 aphereses; CD34+ cell and CFU counts were analyzed.

    • Main Results:

    • PBPC mobilization significantly increased circulating progenitor cells, with efficient collection.
    • Median CD34+ cells: 11.7 x 10(6)/kg; median CFU: 70.3 x 10(4)/kg.
    • Hematologic recovery was rapid and comparable after both transplant courses (neutrophil recovery: 9 days; platelet independence: 8 days).

    Conclusions:

    • PBPC mobilization is effective for collecting sufficient progenitor cells for tandem transplantation.
    • Sequential myeloablative therapy with PBPC transplantation leads to rapid hematologic recovery.
    • PBPC transplantation alone or with bone marrow shows similar engraftment rates.