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Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients
P Atkison1, G Joubert, A Barron
1Children's Hospital of Western Ontario, University of Western Ontario, London, Canada.
Lancet (London, England)
|April 8, 1995
Abstract:
Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.