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Anticoagulant associated hematuria: a prospective study
1Department of Surgery, University of North Carolina, Chapel Hill, USA.
The Journal of Urology
|May 1, 1995
Summary
Anticoagulant-associated hematuria, or blood in urine, often signals underlying genitourinary conditions. Prompt urological evaluation is recommended for patients experiencing this symptom.
Area of Science:
- Urology
- Nephrology
- Internal Medicine
Background:
- Anticoagulant therapy is widely used for various medical conditions.
- Hematuria (blood in urine) can be a concerning side effect of anticoagulant use.
- The underlying causes of hematuria in patients on anticoagulants require thorough investigation.
Purpose of the Study:
- To investigate the prevalence of significant genitourinary pathology in patients presenting with hematuria while on anticoagulant therapy.
- To determine the diagnostic yield of urological evaluation in this patient cohort.
Main Methods:
- Prospective study of 32 consecutive patients with new-onset gross or microscopic hematuria during anticoagulant therapy.
- All patients underwent comprehensive urological evaluation.
- Data collected on patient demographics, hematuria type, and identified genitourinary conditions.
Main Results:
- Significant genitourinary disease was identified in 9 out of 32 patients (30%).
- Conditions included neoplastic disease (2%), benign prostatic hyperplasia (3%), urethral stricture (3%), ureteropelvic junction obstruction (3%), and nephrolithiasis (6%).
- Hematuria resolved in over 90% of patients following appropriate treatment.
Conclusions:
- Anticoagulant-associated hematuria frequently indicates an underlying genitourinary pathological condition.
- Prompt and thorough urological evaluation is crucial for diagnosing and managing these patients.
- Early intervention leads to high rates of hematuria resolution.