Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Class I MHC-peptide interactions: structural requirements and functional implications

H M Grey1, J Ruppert, A Vitiello

  • 1Cytel, San Diego, California 92121, USA.

Cancer Surveys
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antimicrobial resistance and gene therapy: emerging molecular strategies for a global health threat.

Gene therapy·2026
Same author

Long Covid Syndrome and Role of Autonomic Nervous System.

Reviews in medical virology·2025
Same author

From biowaste to innovation: Development of composite nanoparticles from lignin-rich agricultural byproduct.

International journal of biological macromolecules·2025
Same author

Generalizability of a Musculoskeletal Therapist Electronic Health Record for Modelling Outcomes to Work-Related Musculoskeletal Disorders.

Journal of occupational rehabilitation·2024
Same author

Electronic Health Records for Predicting Outcomes to Work-Related Musculoskeletal Disorders: A Scoping Review.

Journal of occupational rehabilitation·2024
Same author

New emerging SARS-CoV-2 variants and antiviral agents.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy·2023
Same journal

Future directions: bladder cancer.

Cancer surveys·2004
Same journal

Radiotherapy and chemotherapy for invasive bladder cancer.

Cancer surveys·2004
Same journal

The role of surgery in the multimodality treatment of bladder cancer.

Cancer surveys·2004
Same journal

Clonal development of bladder cancer and its relevance to the clinical potential of HLA antigen and TP53 based gene therapy.

Cancer surveys·2004
Same journal

Clinical evaluation of immunotherapy: are there differences between papillary and flat in situ bladder cancer?

Cancer surveys·2004
Same journal

Molecular biological changes in bladder cancer.

Cancer surveys·2004
See all related articles

This study identifies specific structural motifs for peptide binding to common human leukocyte antigen A (HLA-A) alleles. These motifs accurately predict high-affinity binders, crucial for developing effective peptide-based vaccines.

Area of Science:

  • Immunology
  • Molecular Biology
  • Vaccine Development

Background:

  • Human Leukocyte Antigen A (HLA-A) alleles are crucial for immune response.
  • Understanding peptide-HLA-A binding is key to vaccine design.
  • Common HLA-A alleles vary across ethnic populations.

Purpose of the Study:

  • To define structural motifs dictating peptide binding to five common HLA-A alleles.
  • To assess the predictive power of these motifs for high-affinity binders.
  • To explore the correlation between MHC binding affinity and immunogenicity for vaccine applications.

Main Methods:

  • Defined structural motifs for peptide binding to specific HLA-A alleles.
  • Tested motifs against nonamer peptides from human papillomavirus E6 and E7 proteins.

Related Experiment Videos

  • Utilized dominant anchor residues and secondary anchor interactions for prediction.

    • Main Results:

    • Peptide motifs were highly specific for individual HLA-A alleles, except for HLA-A*0301 and HLA-A*1101.
    • The majority of high and intermediate binding peptides contained the identified motifs.
    • A direct correlation was found between MHC binding affinity and immunogenicity.

    Conclusions:

    • Structural motifs can accurately predict peptide binding to HLA-A alleles.
    • Predicting high-affinity binders has practical applications in designing peptide-based vaccines.
    • This research supports the development of prophylactic and therapeutic peptide vaccines.