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CD44 expression in normal human skin and skin tumors
The Journal of Dermatology
|February 1, 1995
Summary
CD44 molecule distribution was studied in human skin and tumors. CD44 is present in normal skin cells and most skin tumors, but notably absent in basal cell carcinoma tumor cells.
Area of Science:
- Dermatology
- Cell Biology
- Oncology
Background:
- CD44 is a principal cell surface receptor for hyaluronic acid.
- The distribution of CD44 in human skin and skin tumors is not well understood.
Purpose of the Study:
- To investigate the distribution of the CD44 molecule in normal human skin.
- To examine CD44 expression in benign and malignant skin tumors.
Main Methods:
- Immunohistochemical analysis of CD44 expression.
- Examination of normal skin, seborrheic keratosis, Bowen's disease, squamous cell carcinoma, and basal cell carcinoma tissues.
Main Results:
- CD44 expression was observed in keratinocytes, hair follicle cells, eccrine sweat gland cells, and dermal dendritic cells in normal skin.
- CD44 was present on tumor cells of seborrheic keratosis, Bowen's disease, and squamous cell carcinoma.
- CD44 was not detected on basal cell carcinoma tumor cells, but CD44-positive dendritic cells (likely melanocytes) were present.
Conclusions:
- CD44 exhibits a distinct distribution pattern in normal human skin.
- CD44 expression varies across different types of skin tumors, being absent in basal cell carcinoma.
- CD44-positive melanocytes are present in basal cell carcinoma tissue.