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Novel fluoroprostacyclin analogs with modified cycloalkylenyl chains. Highly potent and orally active anti-anginal
Y Matsumura1, T Asai, T Shimada
1Research Center, Asahi Glass Co., Ltd. Yokohama, Japan.
Chemical & Pharmaceutical Bulletin
|February 1, 1995
Abstract:
Novel fluoroprostacyclin analogs (1a-f) have been synthesized and pharmacologically evaluated. Compounds 1a-c given intravenously or orally showed potent and long-lasting anti-anginal activities in an animal model.