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Effect of transcranial magnetic stimulation on cerebral function in a monkey model
1Department of Orthopedic Surgery, Wakayama Medical College, Wakayama National College of Technology, Japan.
Electroencephalography and Clinical Neurophysiology
|April 1, 1995
Summary
Transcranial magnetic stimulation (TMS) did not impair higher brain functions in monkeys. Studies using a delayed response task showed no deficits or adverse effects like seizures, suggesting TMS is safe for cognitive functions.
Area of Science:
- Neuroscience
- Cognitive Science
- Neuromodulation
Background:
- Higher cerebral functions are crucial for complex behaviors.
- Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technique.
- Understanding TMS effects on cognition is essential for therapeutic applications.
Purpose of the Study:
- To investigate the impact of transcranial magnetic stimulation (TMS) on higher cerebral functions in a primate model.
- To assess potential cognitive deficits or adverse effects following TMS application.
Main Methods:
- Three monkeys were trained on a spatial delayed response task assessing short-term memory.
- Various TMS coil configurations (round, figure 8) and intensities were applied.
- Performance metrics including correct choices, reaction time, and trial number were analyzed.
Main Results:
- No significant deficits in the delayed response task were observed in monkeys receiving TMS.
- No adverse events, such as epileptic seizures, were reported during or after stimulation.
- Over 7000 stimuli were administered across different patterns without apparent negative consequences.
Conclusions:
- Transcranial magnetic stimulation (TMS) does not appear to negatively affect higher cerebral functions in monkeys.
- The findings suggest TMS is a safe neuromodulation technique concerning cognitive performance and neurological stability in this model.