Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The patch clamp technique

L K Liem1, J M Simard, Y Song

  • 1Division of Neurosurgery, University of Maryland School of Medicine, University of Maryland Medical Center, Baltimore, USA.

Neurosurgery
|February 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hardseededness in blackgram (Vigna mungo L.) is related to maternal environment during seed development.

Plant biology (Stuttgart, Germany)·2025
Same author

Pipeline Diameter Significantly Impacts the Long-Term Fate of Jailed Side Branches during Treatment of Intracranial Aneurysms.

AJNR. American journal of neuroradiology·2018
Same author

α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke.

Journal of neuropathology and experimental neurology·2017
Same author

ROBOTIC SURGERY INCREASES PATIENT's ACCESS TO MINIMALLY INVASIVE SURGERY FOR HYSTERECTOMIES: IGCS-0098 Uterine Cancer, including Sarcoma.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2015
Same author

Costs of treatment for elderly women with advanced ovarian cancer in a Medicare population.

Gynecologic oncology·2015
Same author

Should critical care medicine be a formal part of the undergraduate curriculum?

Journal of intensive care medicine·2014
Same journal

Microsurgical Evacuation Efficacy and Functional Outcomes in Spontaneous Intracerebral Hemorrhage by Type of Antithrombotic Therapy.

Neurosurgery·2026
Same journal

Neurosurgeons Are Essential in the Interdisciplinary Care of Patients With Brain Metastasis.

Neurosurgery·2026
Same journal

Performance of Risk Scores in Predicting Intracranial Aneurysm Instability.

Neurosurgery·2026
Same journal

Electric-Scooters: An Emerging Source of High-Severity Pediatric Head Trauma.

Neurosurgery·2026
Same journal

Survival After Surgery for Spinal Osteosarcoma and the Role of Chemotherapy and Treatment Sequencing: A National Cohort Multivariable Analysis.

Neurosurgery·2026
Same journal

Safety and Efficacy of 3-Month Versus 6-Month Duration of Dual Antiplatelet Therapy in Pipeline Embolization Treatment of Intracranial Aneurysms.

Neurosurgery·2026
See all related articles

The patch clamp technique revolutionized cellular physiology by enabling high-resolution study of individual ionic channels. This method offers molecular insights into cellular functions and disease mechanisms, aiding treatment development.

Area of Science:

  • Cellular Physiology
  • Molecular Biology
  • Electrophysiology

Background:

  • The patch clamp technique, developed less than two decades ago, has transformed cellular physiology research.
  • It provides high-resolution observation of individual ionic channel function in various cell types, both normal and pathological.

Purpose of the Study:

  • To provide a historical perspective on the development of the patch clamp technique.
  • To offer an overview of current patch clamp methodologies.
  • To illustrate the diverse applications and configurations of the patch clamp method.

Main Methods:

  • Utilizing variations of the basic patch clamp recording methodology.
  • Combining patch clamp electrophysiology with molecular biological techniques.

Related Experiment Videos

  • Examining cellular processes like signaling, secretion, and synaptic transmission.

    • Main Results:

    • High-resolution observation of ionic channel function at a molecular level.
    • Insights into gene expression and protein structure of ionic channels.
    • Understanding disease mechanisms and potential therapeutic targets related to ionic channels.

    Conclusions:

    • The patch clamp technique is a powerful tool for studying ionic channels and cellular function.
    • It has significantly advanced our understanding of physiological processes and diseases.
    • The review highlights the advantages and disadvantages of various patch clamp configurations.