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Peptide cholesystokinin receptor antagonist increases food intake in rats
1Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520, USA.
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|February 1, 1995
Abstract:
An analogue of the C-terminal heptapeptide of cholecystokinin (CCK) t-Boc-Tyr(SO3-)-Nle-Gly-D-Trp-Nle-Asp-a-2-phenylethylester is a potent, specific CCK receptor antagonist. Intraperitoneal injection of the antagonist abolished suppression of real feeding and sham feeding by exogenous CCK-8 (1.8 nmol/kg), and significantly increased real feeding. Assuming an antagonist distribution like that of exogenous CCK-8, our results suggest that exogenous CCK-8 and endogenous CCK reduce food intake by acting at a site(s) accessible to peripherally administered peptides.