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Identification of tumour-specific translocations in archival material
1Department of Pathology, Cambridge University, Addenbrookes Hospital, U.K.
The Journal of Pathology
|March 1, 1995
Abstract:
A reverse transcriptase nested polymerase reaction (RT-nPCR) method has been developed to detect the presence of a tumour-specific translocation in archival formalin-fixed, paraffin-embedded tissue. This technique can be applied to the large numbers of tumours in pathology departments' archives, allowing correlation of translocations with morphological diagnosis, response to therapy, and survival.