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Dramatic prostate specific antigen decrease in response to discontinuation of megestrol acetate in advanced prostate

N A Dawson1, D G McLeod

  • 1Hematology-Oncology Services, Walter Reed Army Medical Center, Washington, D.C., USA.

The Journal of Urology
|June 1, 1995
PubMed

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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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