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Recurrent anaplastic ependymoma with an abnormal karyotype and c-myc proto-oncogene overexpression
M Debiec-Rychter1, J Lasota, J Alwasiak
1Department of Oncology, Medical Academy of Lodz, Poland.
Acta Neuropathologica
|January 1, 1995
Abstract:
Cytogenetic analysis on a supratentorial, recurrent, anaplastic ependymoma from a 29-year-old female disclosed the presence of an abnormal clone with the karyotype 46,XX,der(8)t(8;11)(q24;p11),-11,add(?)t(?;11)(?;q13). By the Northern hybridization assay and immunohistochemical staining, tumor cells revealed overexpression of c-myc proto-oncogene, although no evidence of amplification or structural rearrangement of this gene was found.