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Somatostatin receptor activation of cellular effector systems
1Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Cellular Signalling
|January 1, 1995
Abstract:
Somatostatin (SRIF) induces its multiple biological actions by interacting with a family of receptors, referred to as SSTR1-SSTR5. These receptors are capable of associating with particular guanine nucleotide binding proteins to couple the receptors to distinct cellular effector systems. Therefore, G proteins have an important role in directing SRIF signalling and may provide the molecular basis for the diverse cellular actions of SRIF.