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Olfaction and multiple chemical sensitivity

R L Doty1

  • 1Smell and Taste Center, University of Pennsylvania Medical Center, Philadelphia, USA.

Toxicology and Industrial Health
|July 1, 1994
PubMed
Summary
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Multiple Chemical Sensitivity (MCS) patients show increased nasal airflow resistance and heart rate, but not altered odor detection thresholds for specific chemicals. Further research is needed to explore other chemical sensitivities.

Area of Science:

  • Neuroscience
  • Environmental Health
  • Psychology

Background:

  • Olfactory anatomy and function testing procedures are reviewed.
  • Limited quantitative data exists on olfactory function in Multiple Chemical Sensitivity (MCS).

Purpose of the Study:

  • To present findings on olfactory function in patients with apparent Multiple Chemical Sensitivity (MCS).

Main Methods:

  • Review of olfactory anatomy and function testing.
  • Analysis of a single study quantitatively examining olfactory function in MCS patients.
  • Evaluation of odor detection thresholds for phenyl ethyl alcohol and methyl ethyl ketone.

Main Results:

  • MCS patients exhibited increased nasal airflow resistance, respiration rate, and heart rate.

Related Experiment Videos

  • Higher scores on the Beck Depression Inventory were noted in MCS patients.
  • No significant changes in odor detection thresholds were found for the tested chemicals.

    • Conclusions:

    • Apparent MCS is associated with physiological changes but not necessarily altered odor detection sensitivity to specific compounds.
    • The question of hypersensitivity to other chemicals in MCS patients remains unanswered.