Glycans and the modulation of neural-recognition molecule function

Neural-recognition molecules are carbohydrate-bearing glycoproteins, glycolipids or proteoglycans that are found at the cell surface or in the extracellular matrix that regulate cell interactions during development, modification of synaptic activity and regeneration of nerve connections after damage in the adult. The expression of the carbohydrates appears to be fine tuned to these functions. Among the identified carbohydrates are polysialic acid, a 3'-sulfated glucuronic acid, and oligomannosidic residues. They act not only between apposing partner cell surfaces (trans-interaction) but also between recognition molecules within the surface membrane of one cell (cis-interaction), thereby forming complexes that influence transduction of signals to the cell interior.