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Expression of E-selectin messenger RNA and protein in rheumatoid arthritis
J Kriegsmann1, G M Keyszer, T Geiler
1University of Alabama at Birmingham, Department of Medicine, USA.
Objective:
To examine the de novo synthesis and cellular distribution of the E-selectin adhesion molecule in synovial tissues obtained from patients with rheumatoid arthritis (RA).
Methods:
Immunohistochemistry techniques combined with in situ hybridization were used to examine RA synovium.
Results:
There were numerous endothelial cells positive for E-selectin and E-selectin messenger RNA in the RA synovial membranes. Moreover, E-selectin expression appeared to correlate with inflammatory activity.
Conclusion:
The strong vascular expression of E-selectin indicates an activation of endothelial cells in the recruitment of cells associated with the chronic inflammation of RA.