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Danazol decreases transcription of estrogen receptor gene in human monocytes
1Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
General Pharmacology
|May 1, 1995
Abstract:
1. Administration of danazol for over one month reduced the levels of estrogen receptor (ER) and its mRNA to approximately 50 and 20%, respectively in monocytes. 2. Danazol did not alter the degradation rate of ER mRNA in monocytes. 3. Danazol decreased the transcription rate of ER gene to approximately 50% in monocytes in a run-on assay. 4. Danazol may release estrogen predominance via the reduction of transcription for ER gene, which leads to the reduction of ER mRNA and ER expressions in monocytes.