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Interaction of clozapine with the histamine H3 receptor in rat brain
A A Rodrigues1, F P Jansen, R Leurs
1Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York, N.Y. 10029, USA.
British Journal of Pharmacology
|April 1, 1995
Abstract:
We examined possible interactions between neuroleptics and the histamine H3 receptor and found an interaction of clozapine with this receptor. In competition binding experiments, using the H3 antagonist, [125I]-iodophenpropit, we observed a Ki of 236 +/- 87 nM. Functionally, clozapine was studied on the H3-mediated inhibition of [3H]-5-hydroxytryptamine ([3H]-5-HT) release from rat brain cortex slices. Clozapine acts as an antagonist with an apparent KB value of 79.5 nM.