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[The relationship between P-selectin on platelet membrane and platelet function in chronic cor pulmonale]
1Department of Respiratory Diseases, Zhu Jiang Hospital, First Military Medical University, Guanzhou.
Zhonghua Nei Ke Za Zhi
|January 1, 1995
Summary
Platelet activation, marked by P-selectin, is significantly elevated in chronic cor pulmonale, contributing to increased platelet aggregation and highlighting platelets' role in this condition.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Pulmonology
Background:
- Platelets are crucial in thromboembolic diseases.
- Recurrent pulmonary embolism can lead to pulmonary hypertension.
- P-selectin (GMP140) is a recognized marker for platelet activation.
Purpose of the Study:
- To investigate the role of platelets in chronic cor pulmonale.
- To analyze changes in platelet P-selectin, adhesiveness (PAdT), and aggregation (PAgT).
Main Methods:
- Quantified P-selectin expression on platelet membranes.
- Measured platelet adhesiveness (PAdT) and aggregation (PAgT).
- Assessed levels of von Willebrand factor (vWF) and fibrinogen (Fg).
Main Results:
- Significantly higher P-selectin, PAdT, and PAgT in chronic cor pulmonale compared to controls (P < 0.01).
- Positive correlations found between P-selectin and PAdT (r=0.6831) and PAgT (r=0.7142) (P < 0.01).
- Elevated vWF and Fg levels in chronic cor pulmonale correlated with PAgT (P < 0.05).
Conclusions:
- Platelet activation and aggregation are significantly involved in the pathogenesis of chronic cor pulmonale.
- P-selectin serves as a key indicator of platelet activation in this condition.
- Increased vWF and Fg further contribute to platelet hyperreactivity in chronic cor pulmonale.