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Related Experiment Videos

Benign prostatic hyperplasia

W D Steers1, B Zorn

  • 1Department of Urology, University of Virginia Health Science Center, Charlottesville, USA.

Disease-A-Month : DM
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

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Benign prostatic hyperplasia (BPH) is a common prostate condition in aging men. Therapies range from medication to minimally invasive procedures and surgery, chosen based on symptom severity and patient evaluation.

Area of Science:

  • Urology
  • Andrology
  • Pathology

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • It results from dihydrotestosterone's action on the aging prostate and cellular changes.
  • BPH causes irritative and obstructive urinary symptoms.

Purpose of the Study:

  • To outline the diagnostic process for BPH.
  • To review current therapeutic options for BPH.
  • To correlate treatment strategies with symptom severity and disease progression.

Main Methods:

  • Comprehensive patient evaluation including medical history, physical examination, and laboratory tests (PSA, creatinine, urinalysis).
  • Urodynamic evaluation (pressure-flow studies) for diagnosing obstruction.

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  • Categorization of treatments based on invasiveness and efficacy.

    • Main Results:

    • Minimal symptoms may require no therapy.
    • Alpha-adrenergic blockers (terazosin, doxazosin) manage mild to moderate symptoms.
    • 5-alpha-reductase inhibitors (finasteride) benefit a subset of patients.
    • Minimally invasive treatments show promise for moderate symptoms.
    • Surgery (TURP, open prostatectomy) offers durable relief for severe cases.

    Conclusions:

    • BPH diagnosis requires excluding other causes and assessing urinary tract status.
    • Treatment selection is guided by symptom severity, diagnostic findings, and patient factors.
    • While surgical interventions carry risks, they provide the most effective long-term relief for severe BPH.