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Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation

J C Zúñiga-Pflücker1, D Jiang, M J Lenardo

  • 1Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|June 30, 1995
PubMed
Summary

Tumor necrosis factor alpha (TNF-alpha) and interleukin-1 alpha (IL-1 alpha) induce CD25 expression on early thymocytes, which is essential for T cell development and differentiation.

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