Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuropeptide changes in compressed spinal nerve roots

M Cornefjord1, K Olmarker, D B Farley

  • 1Department of Orthopaedics, Sahlgren Hospital, University of Gothenburg, Sweden.

Spine
|March 15, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High achievers.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2017
Same author

Expression of inflammation/pain-related genes in the dorsal root ganglion following disc puncture in rats.

Journal of orthopaedic surgery (Hong Kong)·2016
Same author

A novel osseointegrated percutaneous prosthetic system for the treatment of patients with transfemoral amputation: A prospective study of 51 patients.

The bone & joint journal·2014
Same author

Evoked thalamic neuronal activity following DRG application of two nucleus pulposus derived cell populations: an experimental study in rats.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2013
Same author

A lactoferrin-derived peptide (PXL01) for the reduction of adhesion formation in flexor tendon surgery: an experimental study in rabbits.

The Journal of hand surgery, European volume·2011
Same author

Voltage-dependent Changes of a Membrane Protein in Lipid Model Membranes: Studies with the Hepatic Asialoglycoprotein Receptor.

Biophysical journal·2009
Same journal

Comparing those Most Satisfied versus Least Satisfied Following Surgery for Cervical Spondylotic Myelopathy: Are there Differences in Baseline Characteristics?

Spine·2026
Same journal

Pseudoarthrosis After Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis: A Multicenter Analysis of Revision Strategies and Outcomes.

Spine·2026
Same journal

To the Editor "Low-Density Lipoprotein Cholesterol and Statin Usage Are Associated With Rates of Pseudarthrosis Following Single-Level Posterior Lumbar Interbody Fusion" by Lavu et al.

Spine·2026
Same journal

Sarcopenia Increases Adjacent Segment Degeneration Risk within 3 Years of Anterior Cervical Discectomy and Fusion.

Spine·2026
Same journal

Two-Year Cervical Alignment Trajectories and Associated Radiographic Factors after Posterior Spinal Fusion for Lenke Type 1 Adolescent Idiopathic Scoliosis.

Spine·2026
Same journal

Association of C7 Laminoplasty and Decompression Construct Length With Postoperative Axial Symptoms After Cervical Expansive Unilateral Open-door Laminoplasty.

Spine·2026
See all related articles

This study found that chronic nerve root compression in pigs significantly increased substance P levels in dorsal root ganglia and nerve roots. Vasoactive intestinal polypeptide (VIP) levels remained unchanged, suggesting substance P

Area of Science:

  • Neuroscience
  • Pain Research
  • Neuropeptide Signaling

Background:

  • Neuropeptides like substance P and VIP are implicated in pain transmission.
  • Altered neuropeptide levels have been observed in models of nerve injury.
  • Understanding these changes is crucial for pain management strategies.

Purpose of the Study:

  • To investigate the impact of chronic nerve root compression on substance P and VIP concentrations.
  • To analyze neuropeptide changes in spinal nerve roots and dorsal root ganglia using a pig model.
  • To elucidate the role of substance P and VIP in experimental nerve root compression.

Main Methods:

  • An experimental model of chronic nerve root compression was established in pigs using an ameroid constrictor.
  • Spinal nerve roots and dorsal root ganglia were sampled after 1 and 4 weeks of compression.

Related Experiment Videos

  • Radioimmunoassay was employed to quantify substance P and VIP concentrations in tissue samples.

    • Main Results:

    • A statistically significant increase in substance P was observed in compressed dorsal root ganglia at both 1 and 4 weeks.
    • Substance P concentration also increased significantly in the nerve root after 1 week, but not after 4 weeks.
    • No significant changes in vasoactive intestinal polypeptide (VIP) levels were detected in either tissue.

    Conclusions:

    • Chronic nerve root compression leads to elevated substance P levels in dorsal root ganglia and, transiently, in the nerve root.
    • Vasoactive intestinal polypeptide (VIP) concentrations do not appear to be affected by this compression model.
    • These findings suggest a specific role for substance P in the pathophysiology of experimental chronic nerve root compression.