Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-specific reference ranges for serum prostate-specific antigen

J R Anderson1, D Strickland, D Corbin

  • 1Department of Preventive and Societal Medicine, University of Nebraska Medical Center, Omaha 68198-4350, USA.

Urology
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Habitat and climate influence hybridization among three genetically distinct Canada jay (Perisoreus canadensis) morphotypes in an avian hybrid zone complex.

Heredity·2023
Same author

The spectrum of neuropsychiatric lupus in a Black Caribbean population: a report of the Barbados National Lupus Registry.

Lupus·2017
Same author

Cord blood Streptococcus pneumoniae-specific cellular immune responses predict early pneumococcal carriage in high-risk infants in Papua New Guinea.

Clinical and experimental immunology·2016
Same author

Nonlinear laser pulse response in a crystalline lens.

Optics letters·2016
Same author

Effect of multiphoton ionization on performance of crystalline lens.

Optics letters·2014
Same author

Association between maternal inflammatory bowel disease and adverse perinatal outcomes.

Journal of perinatology : official journal of the California Perinatal Association·2014

Serum prostate-specific antigen (PSA) levels increase with age. New age-specific PSA ranges are proposed to improve accuracy for men aged 40-79, enhancing prostate cancer screening.

Area of Science:

  • Urology
  • Biochemistry
  • Public Health

Background:

  • Serum prostate-specific antigen (PSA) is a biomarker used in prostate cancer screening.
  • Established PSA reference ranges may not accurately reflect age-related variations in concentration.
  • Health fairs provide opportunities for large-scale health screenings.

Purpose of the Study:

  • To determine the relationship between serum PSA levels and age in a broad population.
  • To evaluate existing age-specific PSA reference ranges.
  • To propose updated, age-stratified PSA reference ranges.

Main Methods:

  • Serum PSA levels were measured in 1716 men aged 40-79 years.
  • Data was collected during a health fair screening event.
  • Statistical analysis assessed the correlation between PSA concentration and patient age, accounting for heteroscedasticity.

Related Experiment Videos

Main Results:

  • Serum PSA concentration significantly correlated with patient age.
  • The 95th percentile of PSA increased from 1.5 ng/mL (ages 40-44) to 7.7 ng/mL (ages 75-79).
  • Variability of PSA levels increased with age, necessitating age-specific adjustments.

Conclusions:

  • Existing PSA reference ranges may be inaccurate for specific age groups, potentially leading to over- or under-diagnosis.
  • Updated age-specific upper limits for PSA are proposed: 1.5 ng/mL (40-49), 2.5 ng/mL (50-59), 4.5 ng/mL (60-69), and 7.5 ng/mL (70-79).
  • These revised ranges aim to achieve approximately 95% specificity in screening.