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Primary haemostasis in thyroid disease

B Myrup1, C Bregengård, J Faber

  • 1Department of Medical Endocrinology, Frederiksberg Hospital, Copenhagen, Denmark.

Journal of Internal Medicine
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

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Hypothyroidism commonly causes bleeding issues due to altered primary hemostasis, which improves with levothyroxine treatment. This study confirms primary hemostasis changes in hypothyroidism are resolvable.

Area of Science:

  • Endocrinology
  • Hematology
  • Internal Medicine

Background:

  • Bleeding tendencies have been reported in hypothyroidism, potentially mimicking von Willebrand's disease.
  • Primary hemostasis, crucial for blood clotting, may be affected by thyroid dysfunction.

Purpose of the Study:

  • To investigate if altered primary hemostasis is a general characteristic of thyroid disease.
  • To determine the impact of hypothyroidism and hyperthyroidism on primary hemostasis.

Main Methods:

  • Studied 10 hyperthyroid and 9 hypothyroid patients at diagnosis and after achieving euthyroidism through treatment.
  • Assessed template bleeding time and maximal agglutination velocity using ristocetin.
  • Measured von Willebrand factor antigen levels in plasma.

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Main Results:

  • Untreated hypothyroidism showed prolonged bleeding time and decreased maximal agglutination velocity compared to controls.
  • Hypothyroid patients had significantly lower von Willebrand factor antigen levels than hyperthyroid patients.
  • These hemostatic abnormalities resolved upon achieving euthyroidism.

Conclusions:

  • Altered primary hemostasis is a common feature of hypothyroidism.
  • Levothyroxine treatment effectively resolves these hemostatic changes, restoring normal primary hemostasis.