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Published on: April 18, 2011
Serotonergic modulation of locust motor neurons
1Department of Zoology, University of Cambridge, United Kingdom.
Journal of Neurophysiology
|March 1, 1995
Summary
Serotonin (5-HT) enhances locust motor neuron function by broadening action potentials and increasing synaptic transmission. This neuromodulation, mediated by cyclic AMP, potentiates motor output during locomotion.
Area of Science:
- Neuroscience
- Insect Physiology
- Motor Control
Background:
- Serotonin (5-HT) is a key neuromodulator in the nervous system.
- Locust motor neurons control leg movements crucial for locomotion.
Purpose of the Study:
- To investigate the effects of serotonin (5-HT) on fast extensor and flexor tibiae motor neurons in locusts.
- To elucidate the cellular mechanisms underlying 5-HT modulation of these motor neurons.
Main Methods:
- Electrophysiological recordings from locust metathoracic ganglion.
- Application of 5-HT, imipramine, ketanserin, cyclic AMP analogues, and inhibitors.
- Intracellular injection of cyclic AMP.
Main Results:
- 5-HT broadened fast extensor neuron spikes and increased excitatory postsynaptic potential (EPSP) amplitude in flexor neurons.
- 5-HT increased membrane resistance in both neuron types.
- Effects were mimicked by cyclic AMP and blocked by protein kinase A inhibitors, suggesting a cAMP-dependent pathway.
Conclusions:
- Serotonin (5-HT) modulates locust leg motor neurons, enhancing synaptic transmission and potentiating neuronal inputs.
- This modulation likely involves the cyclic AMP pathway and affects motor output during locomotion.
