Related Experiment Video
Updated: Aug 8, 2026

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
Published on: May 27, 2015
Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the
S J Galli1, M Tsai, B K Wershil
1Department of Pathology, Beth Israel Hospital, Boston, MA 02215, USA.
Abstract:
Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-oncogene, has many important effects in mouse and human mast cell development, survival, and function. SCF can promote mast cell survival by suppressing apoptosis, induce mast cell hyperplasia in murine rodents, experimental primates and humans, directly induce SCFR-dependent mast cell mediator release, and significantly modulate the extent of mast cell activation by Fc epsilon RI-dependent mechanisms. These findings raise several clinical issues and, in some cases, point to potentially significant therapeutic opportunities.
Related Concept Videos
Mitogens and the Cell Cycle
Receptor Downregulation in MVBs
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
Differentiation of Common Myeloid Progenitor Cells
Regulation of Hematopoietic Stem Cells
Mesenchymal Stem Cells
MAPK Signaling Cascades

