Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Systemic CD56+ cells can predict pregnancy outcome

C B Coulam1, C Goodman, R G Roussev

  • 1Genetics & IVF Institute, Fairfax, Virginia 30231, USA.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for Axion Dark Matter from 1.1 to 1.3 GHz with ADMX.

Physical review letters·2025
Same author

ADMX Axion Dark Matter Bounds around 3.3  μeV with Dine-Fischler-Srednicki-Zhitnitsky Discovery Ability.

Physical review letters·2025
Same author

Closing the UK care home data gap - methodological challenges and solutions.

International journal of population data science·2021
Same author

Managing loneliness: a qualitative study of older people's views.

Aging & mental health·2020
Same author

ELECtric Tibial nerve stimulation to Reduce Incontinence in Care homes: protocol for the ELECTRIC randomised trial.

Trials·2019
Same author

Gemcitabine-induced pseudocellulitis: a case report and review of the literature.

Current oncology (Toronto, Ont.)·2019
Same journal

Comment on "Assessing the Impact of Female Genital Mutilation/Cutting on Genital Inflammation and Microbiota Among Kenyan Female sex Workers".

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Targeting Long Noncoding RNA LUCAT1 Alleviates Insulin Resistance of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Blocking HMGB1-Mediated Autophagy.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

A Comparative Analysis of the Immunoglobulin G and M Antibodies Seroprevalence Against Helicobacter pylori, Toxoplasma gondii, and Cytomegalovirus in Women With Preeclampsia.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Platelet Rich Plasma: Pioneering a Paradigm Shift in Subclinical Endometritis Treatment.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Correlation Between Gut Microbiota and Hematological Inflammatory Indices in Full-Term Pregnant Women: An Exploratory Study.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same journal

Genital Immune Correlates of Seroprevalent and Seroincident Herpes Simplex Type 2 Infection Among Women Who Sell Sex in Nairobi, Kenya.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
See all related articles

Elevated CD56+ cells may predict the loss of a normal-karyotype pregnancy in certain women. This finding is crucial for identifying pregnancies at risk and may guide treatment with IVIg for better outcomes.

Area of Science:

  • Immunology
  • Reproductive Medicine
  • Genetics

Background:

  • Circulating CD56+ cells play a role in pregnancy.
  • Understanding their levels is important for evaluating pregnancy success.

Purpose of the Study:

  • To evaluate differences in circulating CD56+ cells between successful and unsuccessful pregnancies.
  • To determine if CD56+ cell levels can predict pregnancy loss.

Main Methods:

  • Prospective study of 114 pregnant women.
  • Flow cytometry used to determine CD56+ cell percentages.
  • Analysis included women with infertility, recurrent spontaneous abortions, donor egg recipients, ICSI, and multiple gestations.

Main Results:

  • Prevalence of elevated CD56+ cells (>12%) varied across subgroups (e.g., 73% in ICSI, 22% in singleton gestations).

Related Experiment Videos

  • Women with elevated CD56+ cells and not undergoing specific treatments had a low live birth rate (11%).
  • Elevated CD56+ cells correlated with normal karyotypes (78%) compared to lower levels (68%, P=0.04).

    • Conclusions:

    • Elevated CD56+ cells predict loss of karyotypically normal conceptus in specific populations (87% specificity, 78% PPV).
    • The test shows high specificity but variable sensitivity across different patient groups.
    • This marker may identify pregnancies at risk for loss that could benefit from IVIg treatment.