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Related Experiment Videos

Screening in general practice

M R Feneley1, M G Kirby, T McNicholas

  • 1Department of Urology, St Bartholomew's Hospital, West Smithfield, London.

Cancer Surveys
|January 1, 1995
PubMed
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Screening for prostate cancer in general practice is feasible, diagnosing 14 cancers in 568 men. However, a significant false positive rate exists, necessitating further large-scale studies to confirm screening benefits.

Area of Science:

  • Urology
  • Oncology
  • General Practice

Background:

  • Prostate cancer screening is a key public health concern.
  • General practice settings offer a potential venue for widespread screening.
  • Assessing the feasibility and yield of prostate cancer screening in primary care is crucial.

Purpose of the Study:

  • To evaluate the technical feasibility and patient acceptability of prostate cancer screening in a general practice setting.
  • To determine the cancer detection rate and characteristics of diagnosed cancers.
  • To identify challenges and potential improvements for future screening programs.

Main Methods:

  • A screening program for prostate cancer was implemented in a general practice setting.
  • Participants underwent screening tests, including Prostate-Specific Antigen (PSA) testing.

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  • Biopsies were performed based on screening results and clinical assessment.

    • Main Results:

    • Screening was technically feasible and generally acceptable to participants.
    • 14 prostate cancers were diagnosed among 568 men screened, a detection rate of 2%.
    • Five detected cancers were locally advanced or metastatic; a considerable false positive rate was observed in the PSA range of 4-10 ng/ml, especially with benign prostatic hyperplasia.

    Conclusions:

    • Prostate cancer screening in general practice is feasible but presents challenges.
    • The detection rate needs to be weighed against the false positive rate and potential for overdiagnosis.
    • A large-scale prospective controlled study is required to establish the definitive benefit of this screening approach.