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Related Experiment Videos

Macroamylasemia associated with ulcerative colitis

Y Fujimura1, C Nishishita, J Uchida

  • 1Department of Medicine, Kawasaki Medical School, Okayama, Japan.

Journal of Molecular Medicine (Berlin, Germany)
|February 1, 1995
PubMed
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Macroamylasemia, a rare condition with bound amylase, was observed in a patient with total colitis ulcerative colitis. This case highlights the importance of considering macroamylasemia in inflammatory bowel disease patients with hyperamylasemia.

Area of Science:

  • Clinical enzymology
  • Gastroenterology
  • Immunology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • Hyperamylasemia, elevated serum amylase, can be associated with UC, often due to pancreatitis.
  • Macroamylasemia is a rare condition characterized by high molecular weight amylase complexes.

Observation:

  • A rare case of macroamylasemia associated with total colitis type ulcerative colitis is presented.
  • Serum amylase isozyme electrophoresis revealed an abnormal broad peak.
  • Biochemical analysis confirmed amylase activity bound to immunoglobulin G (IgG) and precipitated by an anti-lambda chain antibody.

Findings:

  • The patient exhibited macroamylasemia, a complex of amylase with IgG, rather than pancreatitis-induced hyperamylasemia.

Related Experiment Videos

  • Electrophoretic and chromatographic methods confirmed the abnormal amylase complex.
  • Immunoprecipitation studies identified the lambda light chain component of the amylase-IgG complex.

    • Implications:

    • This case expands the understanding of potential causes of hyperamylasemia in inflammatory bowel disease.
    • It underscores the necessity of differentiating macroamylasemia from pancreatitis in UC patients presenting with elevated amylase.
    • Diagnosing macroamylasemia in UC is crucial for appropriate patient management and avoiding unnecessary investigations for pancreatitis.