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Aggressive pleomorphic CD2+, CD3-, CD56+ lymphoma with t(5;9)(q31;q34) abnormality
Cancer Genetics and Cytogenetics
|July 1, 1995
Summary
CD56-positive lymphoma, a rare aggressive cancer, often presents outside lymph nodes. This case highlights unusual bone marrow and spinal cord involvement with pleomorphic cells and a t(5;9) translocation, requiring further study.
Area of Science:
- Hematology
- Oncology
- Cytogenetics
Background:
- CD56-positive lymphoma is a recently identified hematologic malignancy.
- It is characterized by extranodal disease and an aggressive clinical course.
Observation:
- A unique case of CD56-positive lymphoma involving the bone marrow and spinal cord at initial diagnosis is presented.
- The lymphoma cells exhibited significant pleomorphism, an atypical feature for this entity.
- The patient also presented with reactive hemophagocytic syndrome.
Findings:
- Cytogenetic analysis revealed a specific chromosomal abnormality: t(5;9)(q31;q34).
- This finding suggests a potential recurring translocation in aggressive CD56-positive lymphomas.
Implications:
- Further investigation into this chromosomal translocation is warranted.
- Understanding this genetic abnormality may aid in diagnosing and classifying aggressive CD56-positive lymphomas.
- This case expands the known clinical and pathological spectrum of CD56-positive lymphoma.