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Taxol encapsulation in poly(epsilon-caprolactone) microspheres
S K Dordunoo1, J K Jackson, L A Arsenault
1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Cancer Chemotherapy and Pharmacology
|January 1, 1995
Abstract:
Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.