Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Taxol encapsulation in poly(epsilon-caprolactone) microspheres

S K Dordunoo1, J K Jackson, L A Arsenault

  • 1Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.

Cancer Chemotherapy and Pharmacology
|January 1, 1995
PubMed
Summary

Poly(epsilon-caprolactone) (PCL) microspheres effectively encapsulated taxol, showing significant inhibition of blood vessel growth in the chick chorioallantoic membrane (CAM) model. This suggests potential for PCL microspheres in anti-angiogenesis therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letters.

The Physician and sportsmedicine·2016
Same author

Development and in vitro characterization of paclitaxel and docetaxel loaded into hydrophobically derivatized hyperbranched polyglycerols.

International journal of pharmaceutics·2010
Same author

Spectral rradiances as determined through the use of prism and filter spectroradiometric techniques.

Applied optics·2010
Same author

Topoisomerase inhibitors as anti-arthritic agents.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2008
Same author

Stream insect occupancy-frequency patterns and metapopulation structure.

Oecologia·2006
Same author

The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2006

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Vascular Biology

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and metastasis.
  • Developing effective drug delivery systems for anti-angiogenic agents is a key challenge in cancer therapy.
  • Poly(epsilon-caprolactone) (PCL) is a biodegradable polymer widely used in biomedical applications.

Purpose of the Study:

  • To prepare and characterize Poly(epsilon-caprolactone) (PCL) microspheres loaded with taxol.
  • To evaluate the in vitro drug release profile of taxol from PCL microspheres.
  • To assess the anti-angiogenic potential of taxol-loaded PCL microspheres using the chick chorioallantoic membrane (CAM) model.

Main Methods:

  • Taxol-loaded PCL microspheres were fabricated using the solvent evaporation technique.

Related Experiment Videos

  • Encapsulation efficiency was determined using established analytical methods.
  • In vitro drug release was monitored over a six-week period.
  • The anti-angiogenic activity was evaluated on the chick chorioallantoic membrane (CAM) model.

    • Main Results:

    • High encapsulation efficiency (95%) of taxol within PCL microspheres was achieved.
    • A sustained release of approximately 25% of the loaded taxol was observed over six weeks from microspheres containing 5% taxol.
    • Taxol released from PCL microspheres demonstrated significant vascular regression and inhibition of angiogenesis in the CAM model.

    Conclusions:

    • PCL microspheres provide an effective system for the encapsulation and sustained release of taxol.
    • Taxol delivered via PCL microspheres exhibits potent anti-angiogenic properties.
    • These findings support the potential of taxol-loaded PCL microspheres as a therapeutic strategy for inhibiting angiogenesis.