[Structure and function of cell adhesion molecules in selectin family and their roles in cancer metastasis]
R Kannagi1, N Kawakami, T Narita
1Laboratory of Experimental Pathology, Aichi Cancer Center, Research Institute.
Abstract:
Cell adhesion molecules of selectin family are involved in the metastasis of cancer at the step of attachment of cancer cells to endothelial cells. P-selectin mediated adhesion of cancer cells with platelets, and L-selectin mediated adhesion of leukocytes to cancer cells would also be involved in the process of hematogenous metastasis through the microthrombus formation. Upon adhesion to cancer cells, platelets and leukocytes secrete cytokines that induce E-selectin expression of endothelial cells, and this further facilitates hematogenous metastasis.
More Related Videos
Related Concept Videos
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Integrins
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
Cell Adhesion Molecules - Types and Functions
CAM Families
The Integrin family of proteins is primarily involved in a...
Selectins
Immunoglobulin-like Cell Adhesion Molecules
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Cell Adhesion Molecules - Types and Functions
CAM Families
The Integrin family of proteins is primarily involved in a...


