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Circulating selectin- and immunoglobulin-type adhesion molecules in acute ischemic stroke
K Fassbender1, R Mössner, L Motsch
1Department of Neurology, Klinikum Mannheim, University of Heidelberg, FRG.
Stroke
|August 1, 1995
Summary
This study reveals chronic changes in soluble intercellular adhesion molecule-1 (sICAM-1) and soluble L-selectin in individuals with vascular risk factors. Acute ischemic stroke patients showed transient increases in soluble endothelial leukocyte adhesion molecule-1 (sELAM-1) and persistent increases in soluble vascular cell adhesion molecule-1 (sVCAM-1).
Area of Science:
- Biomedical science
- Immunology
- Neurology
Background:
- Cellular adhesion molecules are crucial for leukocyte extravasation at injury sites.
- Understanding circulating adhesion molecule patterns is key in acute ischemic stroke.
Purpose of the Study:
- To characterize the release patterns of circulating adhesion molecules in acute ischemic stroke patients.
- To investigate alterations in adhesion molecules in individuals with vascular risk factors.
Main Methods:
- Serum concentrations of sELAM-1, sL-selectin, sVCAM-1, and sICAM-1 were measured serially in 22 acute ischemic stroke patients.
- Control groups included 40 individuals with vascular risk factors and 22 without, matched for age and sex.
Main Results:
- Patients with vascular risk factors exhibited elevated sICAM-1 and reduced sL-selectin, independent of stroke.
- Acute stroke cases showed an initial transient rise in sELAM-1 and a sustained increase in sVCAM-1.
Conclusions:
- Chronic alterations in sICAM-1 and sL-selectin expression are linked to atherosclerosis risk factors.
- Acute ischemic stroke triggers acute changes in sELAM-1 and sVCAM-1 levels.
- Soluble adhesion molecule levels may enable in vivo monitoring of leukocyte-mediated brain damage in stroke.