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Ionophoretically applied substance P activates hamster suprachiasmatic nucleus neurons
H D Piggins1, D J Cutler, B Rusak
1Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.
Brain Research Bulletin
|January 1, 1995
Abstract:
ionophoretic ejection of substance P (SP) activated 31% and suppressed 9% of hamster suprachiasmatic nucleus (SCN) cells in vitro. Hamster SCN cells did not demonstrate variation in sensitivity to SP across the circadian phases tested. SP modulated the response of 47% of hamster SCN cells to the excitatory amino acid (EAA) agonists glutamate and N-methyl-D-aspartate (NMDA). The results indicate that SP can alter both the spontaneous and EAA-evoked firing rate characteristics of hamster SCN neurons.