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Updated: Jul 28, 2026

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
Published on: September 17, 2013
[Biochemistry, molecular mechanism of action and biological effects of endotoxin]
1Abteilung für Infektionen, Universitätsklinik für Innere Medizin I, Wien.
Abstract:
This review is a brief attempt at providing an overview of a subject of enormous complexity-endotoxins and the mediators associated with its biological effects. More specifically it deals with biochemistry and biology of endotoxin, detection of endotoxin with the Limulus amebocyte lysate test, the molecular mechanisms and biological effects, and in the last part with future aspects of therapeutical strategies. It seems certain that the subject will become even more complex and possibly controversial as scientific knowledge further involves. However, because of the high mortality rate of patients suffering from gram-negative sepsis all efforts have to be made to find effective therapeutical strategies.
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