Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart rate decrease after inhibition of nitric oxide release in the anaesthetized dog

P Pagliaro1, D Gattullo, A Merletti

  • 1Department of Human Anatomy and Physiology University of Torino.

Bollettino Della Societa Italiana Di Biologia Sperimentale
|March 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches.

GeroScience·2020
Same author

Apelin-induced cardioprotection against ischaemia/reperfusion injury: roles of epidermal growth factor and Src.

Acta physiologica (Oxford, England)·2017
Same author

Nanoprecipitated catestatin released from pharmacologically active microcarriers (PAMs) exerts pro-survival effects on MSC.

International journal of pharmaceutics·2016
Same author

Tissue engineering: chondrocyte cultures on type I collagen support. Cytohistological and immunohistochemical study.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology·2016
Same author

Redox signalling and cardioprotection: translatability and mechanism.

British journal of pharmacology·2014
Same author

Injured cardiomyocytes promote dental pulp mesenchymal stem cell homing.

Biochimica et biophysica acta·2014
Same journal

Interaction between electromagnetic waves and auditory organs.

Bollettino della Societa italiana di biologia sperimentale·2002
Same journal

Epibiotic bacteria in the marine ecosystem.

Bollettino della Societa italiana di biologia sperimentale·2002
Same journal

Influence of static magnetic fields on cell viability, necrosis and apoptosis.

Bollettino della Societa italiana di biologia sperimentale·2002
Same journal

Knowledge of brain memory codification as a challenge for the third millennium.

Bollettino della Societa italiana di biologia sperimentale·2002
Same journal

Methyleugenol and eugenol variation in Ocimum basilicum cv. Genovese gigante grown in greenhouse and in vitro.

Bollettino della Societa italiana di biologia sperimentale·2002
Same journal

Prophylaxia of cystine calculosis by alpha-mercaptopropionyl-glycine administered continuously or every other day.

Bollettino della Societa italiana di biologia sperimentale·2002
See all related articles

Inhibition of nitric oxide (NO) synthesis in dogs caused bradycardia, a slower heart rate, without affecting blood pressure or nervous reflexes. This suggests a potential role for myocardial adenosine in NO-mediated heart rate regulation.

Area of Science:

  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Nitric oxide (NO) plays a role in cardiovascular regulation.
  • NO inhibition is known to increase myocardial adenosine levels.

Purpose of the Study:

  • To investigate the mechanism by which nitric oxide (NO) inhibition affects heart rate.
  • To determine if NO inhibition causes bradycardia independently of baroreceptor reflexes.
  • To explore the potential involvement of adenosine in NO-induced bradycardia.

Main Methods:

  • Administration of a nitric oxide (NO) synthesis inhibitor to anesthetized, vagotomized dogs.
  • Infusion of dipyridamole, an adenosine potentiator, in separate canine subjects.
  • Aortic constriction to elicit baroreceptor reflexes and assess sympathetic discharge.

Related Experiment Videos

Main Results:

  • Nitric oxide (NO) inhibition reduced heart rate without increasing arterial pressure in vagotomized dogs.
  • Dipyridamole administration also resulted in bradycardia.
  • Baroreceptor-mediated heart rate reduction remained unchanged after NO inhibition, indicating no involvement of nervous mechanisms.

Conclusions:

  • Nitric oxide (NO) inhibition can induce bradycardia through a non-nervous pathway.
  • Increased myocardial adenosine concentration is a potential mediator of NO inhibition-induced bradycardia.