Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adhesion molecules in scleroderma: collagen binding integrins

T S Kupper1

  • 1Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

International Reviews of Immunology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis.

Clinical and experimental dermatology·2016
Same author

Outcome assessment in cellulitis clinical trials: is telephone follow up sufficient?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2015
Same author

Personal reflections on 25 years of immunodermatology.

The British journal of dermatology·2014
Same author

1,24-Dihydroxyvitamin D₃ (tacalcitol) prevents skin T-cell infiltration.

The British journal of dermatology·2010
Same author

Expression of cell-cycle regulator CDK2-associating protein 1 (p12CDK2AP1) in transgenic mice induces testicular and ovarian atrophy in vivo.

Molecular reproduction and development·2006
Same author

Oral epithelial overexpression of IL-1alpha causes periodontal disease.

Journal of dental research·2004
Same journal

Regulatory T cells in the tumor microenvironment: Mechanisms and clinical implications.

International reviews of immunology·2026
Same journal

Leptin in metabolic-immune crosstalk: Mechanisms of T cell regulation and implications for autoimmune disease therapy.

International reviews of immunology·2026
Same journal

Metabolic alterations in the tumor microenvironment influence the anti-tumor immune function of CD8<sup>+</sup> T cells via epigenetic modifications.

International reviews of immunology·2026
Same journal

Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection.

International reviews of immunology·2026
Same journal

Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota.

International reviews of immunology·2026
Same journal

Upregulation of ADAM10 reinforces CD8<sup>+</sup> T cells toward exhaustion in the TME.

International reviews of immunology·2026
See all related articles

Adhesion molecules are key in scleroderma development. Fibroblast interactions with collagen, involving alpha 2 beta 1 integrin, and factors like TGF-beta and Endothelin-1, are crucial in this fibrotic disease.

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Scleroderma pathogenesis involves complex cellular interactions.
  • Endothelial adhesion molecules facilitate leukocyte extravasation, but mechanisms in scleroderma are unclear.
  • Fibroblast-mediated collagen interactions are critical in fibrotic diseases.

Purpose of the Study:

  • To investigate the role of adhesion molecules in scleroderma.
  • To explore the involvement of fibroblast-specific adhesion molecules in collagen organization.
  • To examine the potential influence of factors like TGF-beta and Endothelin-1 on scleroderma.

Main Methods:

  • Analysis of endothelial adhesion molecule expression in affected tissues.
  • Investigation of fibroblast adhesion molecules, specifically alpha 2 beta 1 integrin.

Related Experiment Videos

  • Assessment of collagen organization and fibroblast force generation.
  • Evaluation of TGF-beta and Endothelin-1 levels in scleroderma.

    • Main Results:

    • Upregulation of endothelial adhesion molecules in scleroderma tissues.
    • Identification of alpha 2 beta 1 integrin's likely role in fibroblast collagen organization and force exertion.
    • Potential link between enhanced collagen organization/contraction and unregulated procollagen production.
    • Elevated levels of TGF-beta and Endothelin-1 in scleroderma.

    Conclusions:

    • Adhesion molecules are pivotal in scleroderma pathogenesis and progression.
    • Fibroblast adhesion molecules, particularly alpha 2 beta 1 integrin, are crucial for collagen matrix remodeling.
    • TGF-beta and Endothelin-1 may significantly contribute to scleroderma's fibrotic and contractile features.